Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 4/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.32 |
| ▸ | VCP | P55072 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140004 | 0.89 | RORC (0.32) | PTGDR2ALDH1A1GRM5FFAR1 | |
| SCHEMBL7145378 | 0.76 | ADRA2A (0.35) | ALDH1A1 | |
| SCHEMBL7704027 | 0.76 | FFAR1 (0.49) | PTGDR2ALDH1A1FFAR1GAA | |
| SCHEMBL7143235 | 0.73 | MAPK14 (0.39) | — | |
| SCHEMBL7143481 | 0.72 | RORC (0.35) | GRM5 | |
| SCHEMBL1324044 | 0.67 | TDP1 (0.61) | ALDH1A1FFAR1PKMGAA | |
| SCHEMBL7146584 | 0.67 | — | — | |
| SCHEMBL7699272 | 0.66 | GAA (0.39) | ALDH1A1GRM5FFAR1GAA | |
| SCHEMBL9999540 | 0.66 | ALDH1A1 (0.64) | ALDH1A1PKM | |
| SCHEMBL7703655 | 0.65 | PIK3CA (0.38) | ALDH1A1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |