Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | NPY4R | P50391 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | NTSR2 | O95665 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL7701661 | 0.92 | OPRD1 (0.42) | OPRD1OPRM1NPY1RNPY2RNPY4R | |
| Tyrosine SCHEMBL6460603 | 0.85 | SLC7A5 (0.58) | OPRD1OPRM1THRBLTA4HERAP2 | |
| Tyrosine SCHEMBL4586603 | 0.84 | SLC7A5 (0.60) | NPY1RNPY2RNPY4RTHRBERAP2 | |
| SCHEMBL9197350 | 0.83 | NPY4R (0.62) | OPRD1OPRM1NPY1RNPY2RNPY4R | |
| SCHEMBL413804 | 0.83 | NPY4R (0.56) | OPRM1NPY1RNPY2RNPY4ROPRK1 | |
| SCHEMBL413803 | 0.83 | NPY4R (0.56) | OPRM1NPY1RNPY2RNPY4ROPRK1 | |
| Dl-Phenylalanine SCHEMBL3691104 | 0.82 | SLC7A5 (0.58) | THRBLTA4HOPRK1SLC7A5MMP2 | |
| Phenylalanine SCHEMBL723829 | 0.82 | SLC7A5 (0.58) | THRBLTA4HOPRK1SLC7A5MMP2 | |
| Tyrosine SCHEMBL22654492 | 0.80 | SLC7A5 (0.67) | THRBLTA4HERAP2LNPEPSLC7A5 | |
| Tyrosine SCHEMBL27074660 | 0.80 | SLC7A5 (0.67) | THRBLTA4HERAP2LNPEPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1267170-A1 | Method for characterising polypeptides | Xzillion GmbH & CO.KG (DE) | 2002-12-18 | — | — | EP | disclosed |