Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | HHAT | Q5VTY9 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699731 | 0.88 | PRCP (0.42) | PRCPHHAT | |
| SCHEMBL7701133 | 0.82 | PRCP (0.54) | PRCPHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL7702539 | 0.78 | PRCP (0.46) | PRCPCA1CA2CA9CA14 | |
| SCHEMBL7698116 | 0.76 | TRPM8 (0.45) | PRCPHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL7704956 | 0.76 | CHRM3 (0.47) | PRCPSIGMAR1CA1CA2CA9 | |
| SCHEMBL7697965 | 0.75 | PRCP (0.43) | PRCPHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL7705909 | 0.75 | CYP19A1 (0.44) | PRCPHDAC8 | |
| SCHEMBL7697839 | 0.75 | PRCP (0.43) | PRCPHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL7699278 | 0.75 | HDAC1 (0.51) | PRCPSIGMAR1DRD1CA1CA2 | |
| SCHEMBL7703888 | 0.75 | PRCP (0.39) | PRCPHDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |