Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699773 | 0.76 | PRCP (0.33) | SIGMAR1PRCP | |
| SCHEMBL7702779 | 0.74 | LMNA (0.35) | SMN1; SMN2PRCPALDH1A1LMNAKDM4E | |
| SCHEMBL7701133 | 0.73 | PRCP (0.54) | PRCP | |
| SCHEMBL7705532 | 0.73 | HHAT (0.37) | SIGMAR1GRIN1GRIN2BPRCP | |
| SCHEMBL7705677 | 0.73 | HHAT (0.37) | SIGMAR1GRIN1GRIN2BPRCP | |
| SCHEMBL7698083 | 0.73 | FNTA (0.34) | PRCP | |
| SCHEMBL7706720 | 0.73 | PRCP (0.38) | SIGMAR1PRCPALDH1A1LMNAKDM4E | |
| SCHEMBL8508347 | 0.72 | SMN1; SMN2 (0.39) | SMN1; SMN2CRHBPCRHR2SIGMAR1GRIN1 | |
| SCHEMBL7705565 | 0.72 | CHRM3 (0.35) | SIGMAR1PRCPALDH1A1KDM4E | |
| SCHEMBL7699760 | 0.72 | PRCP (0.36) | PRCPLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |