Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | PRCP | P42785 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705532 | 1.00 | HHAT (0.37) | HHATTRPM8PRCPPPARGSIGMAR1 | |
| SCHEMBL7705731 | 0.87 | TRPM8 (0.36) | TRPM8PRCPPPARGADRA1DADRA1A | |
| SCHEMBL7705666 | 0.87 | GAA (0.36) | TRPM8PRCPPPARGADRA1DADRA1A | |
| SCHEMBL7698066 | 0.86 | TRPM5 (0.40) | HHAT | |
| SCHEMBL7704918 | 0.86 | CYP2D6 (0.42) | HHATPPARG | |
| SCHEMBL7703410 | 0.85 | PRCP (0.35) | HHATTRPM8PRCPPPARGADRA1D | |
| SCHEMBL7698083 | 0.85 | FNTA (0.34) | PRCP | |
| SCHEMBL7700055 | 0.84 | DRD1 (0.41) | SIGMAR1GRIN1GRIN2B | |
| SCHEMBL7705565 | 0.83 | CHRM3 (0.35) | PRCPSIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL7699715 | 0.83 | KDM4E (0.38) | TRPM8PRCPPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |