Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705626 | 0.91 | PARP1 (0.56) | PARP1PARP2LTA4H | |
| SCHEMBL7706352 | 0.90 | PARP1 (0.55) | PARP1PARP2LTA4H | |
| SCHEMBL7706397 | 0.90 | PARP1 (0.55) | PARP1PARP2 | |
| SCHEMBL7700398 | 0.90 | PARP1 (0.55) | PARP1PARP2 | |
| SCHEMBL7705624 | 0.90 | PARP1 (0.55) | PARP1PARP2 | |
| SCHEMBL7702702 | 0.88 | PARP1 (0.55) | PARP1PARP2 | |
| SCHEMBL5620912 | 0.88 | PARP1 (0.53) | PARP1PARP2 | |
| SCHEMBL7706364 | 0.88 | PARP1 (0.53) | PARP1PARP2LTA4H | |
| SCHEMBL7705471 | 0.87 | PARP1 (0.62) | PARP1PARP2LTA4H | |
| SCHEMBL7706390 | 0.87 | PARP1 (0.52) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448271-B1 | SUCH AS 2-(PIPERIDIN-4-YL)BENZIMIDAZOLE-4-CARBOXAMIDE; INHIBITORS OF ENZYME POLY(ADP-RIBOSE)POLYMERASE; IMPROVED WATER SOLUBILITY | BASF AKTIENGESELLSCHAFT (DE) | 2002-09-10 | — | — | US | disclosed |