Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139736 | 0.88 | MAPT (0.40) | MAPTMAPK1ALDH1A1RECQLTDP1 | |
| SCHEMBL7703607 | 0.85 | MAPT (0.40) | MAPTMAPK1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL7704017 | 0.83 | WDR5 (0.49) | MAPTMAPK1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7700599 | 0.79 | HCAR3 (0.39) | MAPTMAPK1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL7139645 | 0.77 | MAPT (0.43) | MAPTMAPK1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL7140157 | 0.76 | MAPT (0.37) | MAPTMAPK1ALDH1A1RECQLTDP1 | |
| SCHEMBL7141821 | 0.74 | MAPT (0.39) | MAPTMAPK1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL7146607 | 0.73 | MAPT (0.44) | MAPTMAPK1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL7143075 | 0.73 | MAPT (0.35) | MAPTMAPK1ALDH1A1NPSR1LMNA | |
| SCHEMBL7700537 | 0.72 | MAPT (0.46) | MAPTMAPK1ALDH1A1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |