Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 8/20 | 0.49 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL7702768 | 0.91 | SLC6A9 (0.60) | SLC6A9SRD5A1FFAR1TACR1 | |
| SCHEMBL7698703 | 0.91 | SLC6A9 (0.59) | SLC6A9SRD5A1HTR6FFAR1TRPV1 | |
| Lithium Ion SCHEMBL7698371 | 0.91 | SLC6A9 (0.53) | SLC6A9SRD5A1HTR6 | |
| SCHEMBL7700515 | 0.86 | SLC6A9 (0.49) | SLC6A9SRD5A1FFAR1RORCTACR1 | |
| Lithium Ion SCHEMBL7706037 | 0.85 | SLC6A9 (0.69) | SLC6A9HTR6 | |
| Lithium Ion SCHEMBL7703444 | 0.85 | SLC6A9 (0.62) | SLC6A9HTR6TACR1 | |
| Lithium Ion SCHEMBL7706198 | 0.85 | SLC6A9 (0.46) | SLC6A9HTR6RORC | |
| Lithium Ion SCHEMBL7704198 | 0.85 | SLC6A9 (0.51) | SLC6A9 | |
| Lithium Ion SCHEMBL7705019 | 0.84 | SLC6A9 (0.56) | SLC6A9HTR6 | |
| SCHEMBL1761236 | 0.83 | SLC6A9 (0.70) | SLC6A9SRD5A1FFAR1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100769-B1 | AMINOMETHYLCARBOXYLIC ACID DERIVATIVES | AKZO NOBEL NV (NL) | 2002-12-04 | — | — | EP | disclosed |
| US-6410592-B1 | THERAPY FOR CENTRAL NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS | AKZO NOBEL N.V. (NL) | 2002-06-25 | — | — | US | disclosed |