Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.56 |
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 9/20 | 0.36 |
| ▸ | PPARG | P37231 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL7706037 | 0.91 | SLC6A9 (0.69) | SLC6A9PPARDCA1CA2CA9 | |
| Lithium Ion SCHEMBL7704525 | 0.91 | SLC6A9 (0.69) | SLC6A9PPARDCA1CA2CA7 | |
| Lithium Ion SCHEMBL7698371 | 0.88 | SLC6A9 (0.53) | SLC6A9ESR1HTR6 | |
| Lithium Ion SCHEMBL7703313 | 0.84 | SLC6A9 (0.74) | SLC6A9PPARDCA1CA2CA7 | |
| Lithium Ion SCHEMBL7702956 | 0.84 | SLC6A9 (0.49) | SLC6A9HTR6 | |
| SCHEMBL1761264 | 0.82 | SLC6A9 (0.81) | SLC6A9PPARDPPARAPPARG | |
| Lithium Ion SCHEMBL7703444 | 0.82 | SLC6A9 (0.62) | SLC6A9HTR6 | |
| Lithium Ion SCHEMBL7706198 | 0.82 | SLC6A9 (0.46) | SLC6A9HTR6 | |
| Lithium Ion SCHEMBL7704198 | 0.82 | SLC6A9 (0.51) | SLC6A9 | |
| Lithium Ion SCHEMBL7706192 | 0.81 | SLC6A9 (0.64) | SLC6A9PPARDCA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100769-B1 | AMINOMETHYLCARBOXYLIC ACID DERIVATIVES | AKZO NOBEL NV (NL) | 2002-12-04 | — | — | EP | disclosed |
| US-6410592-B1 | THERAPY FOR CENTRAL NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS | AKZO NOBEL N.V. (NL) | 2002-06-25 | — | — | US | disclosed |