Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 16/20 | 0.46 |
| ▸ | MEN1 | O00255 | 12/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.46 |
| ▸ | GFER | P55789 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | MARS1 | P56192 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL771768 | 0.82 | CCR3 (0.47) | MEN1KMT2AALDH1A1HTTKDM4E | |
| SCHEMBL770828 | 0.81 | MAPT (0.35) | GAAALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL771344 | 0.80 | KEAP1 (0.46) | HPGDLMNADPP4CCR3 | |
| SCHEMBL769987 | 0.79 | EPHX2 (0.50) | GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL770222 | 0.79 | MEN1 (0.46) | MEN1KMT2AALDH1A1RAB9ADPP4 | |
| SCHEMBL772557 | 0.79 | EPHX2 (0.50) | GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL772293 | 0.79 | DPP4 (0.56) | GAAKMT2AALDH1A1KDM4ERAB9A | |
| SCHEMBL770431 | 0.78 | HTR3A (0.48) | KMT2AMAPTSMN1; SMN2TP53LMNA | |
| SCHEMBL771634 | 0.77 | KEAP1 (0.48) | HPGDLMNADPP4CCR3 | |
| SCHEMBL770000 | 0.77 | POLB (0.44) | MEN1KMT2AALDH1A1HSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822452-B2 | Inhibitor compounds of 11-beta-hydroxysteroid dehydrogenase type 1 | LABORATORIOS SALVAT, S.A. (ES) | 2014-09-02 | — | — | US | disclosed |
| US-20130303522-A1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | LABORATORIOS SALVAT, S.A. (ES) | 2013-11-14 | — | — | US | disclosed |
| US-8524894-B2 | Inhibitor compounds of 11-beta-hydroxysteroid dehydrogenase type 1 | LABORATORIOS SALVAT, S.A. (ES) | 2013-09-03 | — | — | US | disclosed |
| US-20120071466-A1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | LABORATORIOS SALVAT, S.A. (ES) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303522-A1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | HSD11B1, HSD17B1, HSD11B2 | GAA 751/4885MEN1 827/4885KMT2A 3868/4885 |
| US-20120071466-A1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | HSD11B1, HSD17B1, HSD11B2 | GAA 746/4885MEN1 823/4885KMT2A 3893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.