Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.62 |
| ▸ | HTR1B | P28222 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
| ▸ | HTR1F | P30939 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | CCR5 | P51681 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7694620 | 0.93 | CCR2 (0.56) | CCR2HTR1BHTR1ADRD2DRD3 | |
| SCHEMBL7695531 | 0.91 | CCR2 (0.52) | CCR2HTR1BHTR1ADRD2DRD3 | |
| SCHEMBL7702544 | 0.91 | CCR2 (0.62) | CCR2SLC2A1 | |
| SCHEMBL7701607 | 0.91 | SLC2A1 (0.58) | CCR2HTR1BHTR1ADRD2DRD3 | |
| SCHEMBL7699076 | 0.89 | CCR2 (0.52) | CCR2HTR1BHTR1ADRD2HTR1F | |
| SCHEMBL7701596 | 0.88 | CCR2 (0.51) | CCR2HTR1BDRD2HTR1D | |
| SCHEMBL7695961 | 0.88 | HTR1D (0.54) | CCR2HTR1BHTR1ADRD2HTR1F | |
| SCHEMBL7701558 | 0.88 | CCR2 (0.57) | CCR2HTR1BHTR1ADRD2DRD3 | |
| SCHEMBL7696192 | 0.87 | CCR2 (0.58) | CCR2HTR1BDRD2HTR6SLC2A1 | |
| SCHEMBL7700411 | 0.86 | CCR2 (0.51) | CCR2HTR1BDRD2HTR6SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002079190-A1 | 3-SUBSTITUTED INDOLES AS CHEMOKINE ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-10-10 | — | — | WO | disclosed |