Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ITGAV | P06756 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 4/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 3/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7697072 | 0.88 | F2 (0.41) | HPGDF2 | |
| SCHEMBL7704937 | 0.85 | LMNA (0.45) | ALDH1A1SMN1; SMN2LMNAITGAVNPC1 | |
| SCHEMBL7704935 | 0.85 | LMNA (0.45) | ALDH1A1SMN1; SMN2LMNAITGAVNPC1 | |
| SCHEMBL7700493 | 0.80 | ITGB3 (0.47) | ITGAVHPGDF2 | |
| SCHEMBL7700495 | 0.80 | ITGB3 (0.47) | ITGAVHPGDF2 | |
| SCHEMBL7696079 | 0.79 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2LMNAITGAVHPGD | |
| SCHEMBL7696082 | 0.79 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2LMNAITGAVHPGD | |
| SCHEMBL7702556 | 0.75 | MAPT (0.41) | ALDH1A1SMN1; SMN2LMNAHPGDF2 | |
| SCHEMBL7702564 | 0.75 | MAPT (0.41) | ALDH1A1SMN1; SMN2LMNAHPGDF2 | |
| SCHEMBL8356153 | 0.73 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2LMNAITGAVNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6348504-B1 | COMPOUNDS WITH AMIDINE OR GUANIDINE GROUPS AND CARBOXY OR ESTER GROUPS THROMBOLYTICS AND/OR FOR THE TREATMENT OF THROMBOEMBOLIC DISORDERS. | DUPONT PHARMACEUTICALS COMPANY | 2002-02-19 | — | — | US | disclosed |