Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7704937 | 1.00 | LMNA (0.45) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL7696082 | 0.92 | ALDH1A1 (0.44) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL7696079 | 0.92 | ALDH1A1 (0.44) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL7702556 | 0.86 | MAPT (0.41) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL7702564 | 0.86 | MAPT (0.41) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL7703837 | 0.85 | ALDH1A1 (0.45) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL7697136 | 0.79 | ITGB3 (0.45) | ALDH1A1MAPTKMT2AHPGDKDM4E | |
| SCHEMBL7697141 | 0.79 | ITGB3 (0.45) | ALDH1A1MAPTKMT2AHPGDKDM4E | |
| SCHEMBL7698698 | 0.78 | ITGB3 (0.40) | F2 | |
| SCHEMBL7698702 | 0.78 | ITGB3 (0.40) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6348504-B1 | COMPOUNDS WITH AMIDINE OR GUANIDINE GROUPS AND CARBOXY OR ESTER GROUPS THROMBOLYTICS AND/OR FOR THE TREATMENT OF THROMBOEMBOLIC DISORDERS. | DUPONT PHARMACEUTICALS COMPANY | 2002-02-19 | — | — | US | disclosed |