Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 6/20 | 0.57 |
| ▸ | RARB | P10826 | 6/20 | 0.57 |
| ▸ | RARG | P13631 | 3/20 | 0.46 |
| ▸ | RXRA | P19793 | 5/20 | 0.42 |
| ▸ | RXRB | P28702 | 5/20 | 0.42 |
| ▸ | RXRG | P48443 | 5/20 | 0.42 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7712306 | 0.90 | RARA (0.61) | RARARARBRARGRXRARXRB | |
| SCHEMBL7709680 | 0.88 | RARB (0.59) | RARARARBRARGRXRARXRB | |
| SCHEMBL8115004 | 0.82 | RARA (0.69) | RARARARBRARGRXRARXRB | |
| SCHEMBL8118100 | 0.80 | RARA (0.66) | RARARARBRARGRXRARXRB | |
| SCHEMBL7706907 | 0.79 | RARA (0.59) | RARARARBRARGRXRARXRB | |
| SCHEMBL7709721 | 0.78 | RARA (0.63) | RARARARBRARGHTTHPGD | |
| SCHEMBL8116841 | 0.78 | RXRA (0.65) | RARARARBRARGRXRARXRB | |
| SCHEMBL7706886 | 0.78 | RARA (0.71) | RARARARBRARGRXRARXRB | |
| SCHEMBL8115665 | 0.78 | RXRA (0.53) | RARARARBRARGRXRARXRB | |
| SCHEMBL8115666 | 0.77 | RARB (0.57) | RARARARBRARGRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228042-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012606-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6127382-A | AN ANTIPROLIFERATIVE AGENT FOR TREATING SKIN-RELATED DISEASES, AN ANTITUMOR AGENT TREATING CANCER, AN ANTIINFLAMMATORY AGENT TREATING PULMONARY FIBROSIS, ILEITIS, COLITIS AND KROHN'S DISEASE | ALLERGAN SALES, INC. (US) | 2000-10-03 | — | — | US | disclosed |