Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.59 |
| ▸ | RARA | P10276 | 5/20 | 0.59 |
| ▸ | RARG | P13631 | 5/20 | 0.59 |
| ▸ | RXRA | P19793 | 13/20 | 0.52 |
| ▸ | RXRB | P28702 | 12/20 | 0.52 |
| ▸ | RXRG | P48443 | 10/20 | 0.52 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703913 | 0.88 | RARA (0.57) | RARBRARARARGRXRARXRB | |
| SCHEMBL8116841 | 0.88 | RXRA (0.65) | RARBRARARARGRXRARXRB | |
| SCHEMBL7706884 | 0.87 | RARB (0.62) | RARBRARARARGRXRARXRB | |
| SCHEMBL8115665 | 0.87 | RXRA (0.53) | RARBRARARARGRXRARXRB | |
| SCHEMBL8116011 | 0.80 | RXRA (0.65) | RARBRARARARGRXRARXRB | |
| SCHEMBL8123556 | 0.78 | RARB (0.61) | RARBRARARARGRXRARXRB | |
| SCHEMBL8116214 | 0.77 | RXRA (0.69) | RARBRARARARGRXRARXRB | |
| SCHEMBL7710046 | 0.77 | RXRA (0.69) | RARBRARARARGRXRARXRB | |
| SCHEMBL7712306 | 0.77 | RARA (0.61) | RARBRARARARGRXRARXRB | |
| SCHEMBL8113512 | 0.76 | RXRA (0.56) | RARBRARARARGRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228042-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012606-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6127382-A | AN ANTIPROLIFERATIVE AGENT FOR TREATING SKIN-RELATED DISEASES, AN ANTITUMOR AGENT TREATING CANCER, AN ANTIINFLAMMATORY AGENT TREATING PULMONARY FIBROSIS, ILEITIS, COLITIS AND KROHN'S DISEASE | ALLERGAN SALES, INC. (US) | 2000-10-03 | — | — | US | disclosed |