Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.49 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL770746 | 0.96 | NAMPT (0.57) | NAMPTL3MBTL1EPHX2EPHX1FKBP1A | |
| SCHEMBL770878 | 0.92 | NAMPT (0.52) | NAMPTL3MBTL1EPHX2 | |
| SCHEMBL770386 | 0.88 | HRH3 (0.54) | NAMPT | |
| SCHEMBL771571 | 0.87 | NAMPT (0.54) | NAMPTL3MBTL1EPHX2EPHX1GAA | |
| SCHEMBL770384 | 0.86 | HRH3 (0.52) | NAMPTFKBP1ATPSAB1GAA | |
| SCHEMBL771711 | 0.86 | LMNA (0.49) | NAMPTL3MBTL1EPHX2EPHX1HPGD | |
| SCHEMBL770274 | 0.83 | KEAP1 (0.52) | EPHX2EPHX1FKBP1AHPGD | |
| SCHEMBL1677776 | 0.82 | NAMPT (0.44) | NAMPTEPHX2EPHX1FKBP1ATPSAB1 | |
| SCHEMBL770625 | 0.82 | EPHX2 (0.62) | NAMPTL3MBTL1EPHX2EPHX1FKBP1A | |
| SCHEMBL769627 | 0.82 | HDAC3 (0.51) | NAMPTEPHX2EPHX1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130303522-A1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | LABORATORIOS SALVAT, S.A. (ES) | 2013-11-14 | — | — | US | disclosed |
| US-20120071466-A1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | LABORATORIOS SALVAT, S.A. (ES) | 2012-03-22 | — | — | US | disclosed |
| US-20120071466-A1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | LABORATORIOS SALVAT, S.A. (ES) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303522-A1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | HSD11B1, HSD17B1, HSD11B2 | NAMPT 2501/4885L3MBTL1 4097/4885EPHX2 1149/4885 |
| US-20120071466-A1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | HSD11B1, HSD17B1, HSD11B2 | NAMPT 2543/4885L3MBTL1 4090/4885EPHX2 1153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.