Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.34 |
| ▸ | RORC | P51449 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139819 | 0.92 | SIRT2 (0.35) | CREBBPEP300CD274RORC | |
| SCHEMBL7700560 | 0.79 | CREBBP (0.37) | CREBBPEP300CD274KMT2AMEN1 | |
| SCHEMBL7704530 | 0.76 | DHODH (0.37) | CD274KMT2AMEN1PDCD1GRM5 | |
| SCHEMBL7700574 | 0.76 | ALDH1A1 (0.38) | CREBBPEP300KMT2AMEN1 | |
| SCHEMBL7703803 | 0.74 | HTT (0.39) | KMT2AMEN1GRM5 | |
| SCHEMBL6622928 | 0.73 | HSD11B1 (0.33) | CREBBPEP300 | |
| SCHEMBL7145960 | 0.70 | EGLN2 (0.36) | CD274RORCKMT2AMEN1PDCD1 | |
| SCHEMBL7139979 | 0.70 | ALDH1A1 (0.40) | KMT2AMEN1GRM5 | |
| SCHEMBL7141267 | 0.70 | HDAC3 (0.37) | CREBBPEP300CD274 | |
| SCHEMBL6626793 | 0.69 | EP300 (0.33) | CREBBPEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |