Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145960 | 0.92 | EGLN2 (0.36) | DHODHGSK3BMEN1KMT2AHDAC3 | |
| SCHEMBL7703803 | 0.87 | HTT (0.39) | DHODHGSK3BMEN1KMT2ARAB9A | |
| SCHEMBL7704536 | 0.86 | DHODH (0.36) | DHODHMEN1KMT2ARAB9ACD274 | |
| SCHEMBL7139979 | 0.85 | ALDH1A1 (0.40) | GSK3BMEN1KMT2ARAB9AHDAC3 | |
| SCHEMBL7140101 | 0.83 | KCNQ4 (0.36) | GSK3BMEN1KMT2AHDAC3ALDH1A1 | |
| SCHEMBL7142038 | 0.82 | HTT (0.36) | DHODHGSK3BMEN1KMT2AHDAC3 | |
| SCHEMBL7704377 | 0.82 | ALDH1A1 (0.45) | GSK3BMEN1KMT2ARAB9AGRM5 | |
| SCHEMBL7702829 | 0.81 | GAA (0.37) | DHODHMEN1KMT2ARAB9APOLB | |
| SCHEMBL7704182 | 0.80 | CYP3A4 (0.35) | MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL7703510 | 0.80 | VCP (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |