Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 4/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.50 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 5/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710805 | 0.83 | PTGER4 (0.55) | PTGER4PTGER3PTGER1PTGER2MAOB | |
| SCHEMBL7711180 | 0.83 | PTGER4 (0.52) | PTGER4PTGER3PTGER1PTGER2MAOB | |
| SCHEMBL1636426 | 0.81 | BCHE (0.58) | MAOBNR4A2GRM5CYP4F2CYP4A11 | |
| SCHEMBL952649 | 0.80 | HTR7 (0.49) | NAAACYP4F2CYP4A11 | |
| SCHEMBL2085480 | 0.80 | BACE1 (0.45) | PTGER4PTGER3PTGER1PTGER2GRM5 | |
| SCHEMBL379281 | 0.78 | MAOB (0.67) | MAOBNR4A2MRGPRX4GSTP1CYP4F2 | |
| SCHEMBL28451933 | 0.77 | PTGER4 (0.60) | PTGER4PTGER3PTGER1PTGER2MAOB | |
| SCHEMBL17188139 | 0.77 | ALOX5 (0.56) | MAOBNR4A2MRGPRX4 | |
| SCHEMBL2137838 | 0.77 | MRGPRX4 (0.69) | NAAAMAOBNR4A2MRGPRX4GSTP1 | |
| SCHEMBL9032723 | 0.77 | MAOB (0.61) | MAOBNR4A2GRM5MRGPRX4GSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358985-B1 | ANTICANCER AGENT | MERCK & CO., INC. | 2002-03-19 | — | — | US | disclosed |
| EP-1091736-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1091736-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001382-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |