Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094067 | 0.91 | HPGD (0.41) | HSD17B10LMNAMITFMAPTHPGD | |
| SCHEMBL7708055 | 0.87 | PARP1 (0.41) | HSD17B10MAPTHPGDHTTNPSR1 | |
| SCHEMBL7708086 | 0.87 | CTSS (0.43) | SCN9ASMYD3PARP1IDO1 | |
| SCHEMBL7713251 | 0.84 | CTSS (0.45) | HSD17B10LMNAHPGDMAPK1HTT | |
| SCHEMBL7711137 | 0.84 | CTSL (0.45) | HSD17B10LMNAHPGDHTTNPSR1 | |
| SCHEMBL7713423 | 0.83 | PARP1 (0.41) | HSD17B10SMYD3PARP1KDRIDO1 | |
| SCHEMBL7713338 | 0.83 | PARP1 (0.42) | HSD17B10SMYD3PARP1KDRIDO1 | |
| SCHEMBL7708144 | 0.83 | PARP1 (0.42) | HSD17B10LMNAHPGDMAPK1HTT | |
| SCHEMBL7713374 | 0.83 | PARP1 (0.50) | HSD17B10LMNAMAPTHPGDMAPK1 | |
| SCHEMBL7708210 | 0.83 | MC4R (0.41) | HSD17B10MAPTHPGDHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |