Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7093383 | 0.91 | MC4R (0.41) | MC4RSMN1; SMN2TP53HSD17B10IDO1 | |
| SCHEMBL7708055 | 0.91 | PARP1 (0.41) | MC4RHSD17B10KDRIDO1PARP1 | |
| SCHEMBL7713338 | 0.89 | PARP1 (0.42) | SMN1; SMN2TP53HSD17B10KDRIDO1 | |
| SCHEMBL7711137 | 0.86 | CTSL (0.45) | SMN1; SMN2TP53HSD17B10KDRIDO1 | |
| SCHEMBL7713423 | 0.85 | PARP1 (0.41) | SMN1; SMN2TP53HSD17B10KDRIDO1 | |
| SCHEMBL7708086 | 0.84 | CTSS (0.43) | IDO1PARP1ALDH1A1KDM4ESMYD3 | |
| SCHEMBL7713374 | 0.83 | PARP1 (0.50) | SMN1; SMN2TP53HSD17B10IDO1PARP1 | |
| SCHEMBL7710779 | 0.83 | TP53 (0.40) | TP53HSD17B10KDRIDO1PARP1 | |
| SCHEMBL7704807 | 0.83 | HSD17B10 (0.42) | HSD17B10KDRIDO1PARP1HPGD | |
| SCHEMBL7713294 | 0.82 | PARP1 (0.42) | SMN1; SMN2TP53IDO1PARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |