Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HK1 | P19367 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707974 | 0.93 | HCRTR2 (0.53) | SMN1; SMN2LMNANPSR1L3MBTL1HCRTR1 | |
| SCHEMBL7709100 | 0.91 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNANPSR1L3MBTL1HCRTR1 | |
| SCHEMBL7707104 | 0.86 | HCRTR1 (0.47) | SMN1; SMN2LMNANPSR1L3MBTL1HCRTR1 | |
| SCHEMBL2594867 | 0.84 | HCRTR1 (0.45) | SMN1; SMN2LMNANPSR1L3MBTL1HCRTR1 | |
| SCHEMBL7708409 | 0.80 | HCRTR1 (0.68) | SMN1; SMN2LMNANPSR1L3MBTL1HCRTR1 | |
| SCHEMBL2590272 | 0.80 | SIGMAR1 (0.45) | HCRTR1HCRTR2KMT2AGLA | |
| SCHEMBL7703519 | 0.79 | HCRTR2 (0.58) | SMN1; SMN2LMNANPSR1L3MBTL1HCRTR1 | |
| SCHEMBL7713640 | 0.79 | HCRTR2 (0.54) | HCRTR1HCRTR2POLB | |
| SCHEMBL7707039 | 0.77 | HCRTR2 (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL2595050 | 0.77 | HCRTR2 (0.53) | SMN1; SMN2LMNANPSR1L3MBTL1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |