Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713640 | 0.93 | HCRTR2 (0.54) | HCRTR1HCRTR2PTGDR2MAPTPDE5A | |
| SCHEMBL7702319 | 0.90 | HCRTR2 (0.47) | HCRTR1HCRTR2PTGDR2SMN1; SMN2NPSR1 | |
| SCHEMBL2594867 | 0.87 | HCRTR1 (0.45) | HCRTR1HCRTR2PTGDR2LMNASMN1; SMN2 | |
| SCHEMBL7704817 | 0.86 | SMN1; SMN2 (0.55) | HCRTR1HCRTR2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL2590272 | 0.85 | SIGMAR1 (0.45) | HCRTR1HCRTR2MAPT | |
| SCHEMBL2595050 | 0.82 | HCRTR2 (0.53) | HCRTR1HCRTR2PTGDR2LMNASMN1; SMN2 | |
| SCHEMBL7703519 | 0.80 | HCRTR2 (0.58) | HCRTR1HCRTR2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL7707039 | 0.80 | HCRTR2 (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL7707974 | 0.80 | HCRTR2 (0.53) | HCRTR1HCRTR2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL7702650 | 0.79 | HCRTR2 (0.78) | HCRTR1HCRTR2LMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |