Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 3/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.40 |
| ▸ | CFD | P00746 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711206 | 0.94 | HCRTR2 (0.55) | HCRTR2HCRTR1OPRM1TMEM97CFD | |
| SCHEMBL7712435 | 0.94 | HCRTR2 (0.48) | HCRTR2HCRTR1OPRM1TMEM97CFD | |
| SCHEMBL7707104 | 0.80 | HCRTR1 (0.47) | HCRTR2HCRTR1 | |
| SCHEMBL2590272 | 0.80 | SIGMAR1 (0.45) | HCRTR2HCRTR1SIGMAR1 | |
| SCHEMBL7703519 | 0.78 | HCRTR2 (0.58) | HCRTR2HCRTR1 | |
| SCHEMBL7702650 | 0.77 | HCRTR2 (0.78) | HCRTR2HCRTR1 | |
| SCHEMBL7704817 | 0.77 | SMN1; SMN2 (0.55) | HCRTR2HCRTR1 | |
| SCHEMBL2594867 | 0.77 | HCRTR1 (0.45) | HCRTR2HCRTR1 | |
| SCHEMBL7713631 | 0.76 | HCRTR2 (0.61) | HCRTR2HCRTR1 | |
| SCHEMBL2592050 | 0.75 | THRB (0.46) | HCRTR2HCRTR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |