Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 3/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7702319 | 0.94 | HCRTR2 (0.47) | HCRTR2HCRTR1PTGDR2POLBMAPT | |
| SCHEMBL7707104 | 0.93 | HCRTR1 (0.47) | HCRTR2HCRTR1PTGDR2PDE5AHSD17B10 | |
| SCHEMBL2595050 | 0.88 | HCRTR2 (0.53) | HCRTR2HCRTR1PTGDR2PDE5APOLB | |
| SCHEMBL7707974 | 0.86 | HCRTR2 (0.53) | HCRTR2HCRTR1POLBTSHR | |
| SCHEMBL2594744 | 0.85 | HCRTR1 (0.48) | HCRTR2HCRTR1POLBMAPTTSHR | |
| SCHEMBL7702650 | 0.85 | HCRTR2 (0.78) | HCRTR2HCRTR1HSD17B10POLBMAPT | |
| SCHEMBL7708626 | 0.85 | HCRTR1 (0.71) | HCRTR2HCRTR1PTGDR2HSD17B10POLB | |
| SCHEMBL2588992 | 0.81 | HCRTR2 (0.44) | HCRTR2HCRTR1POLBMAPT | |
| SCHEMBL7711206 | 0.81 | HCRTR2 (0.55) | HCRTR2HCRTR1POLBMAPT | |
| SCHEMBL2594867 | 0.81 | HCRTR1 (0.45) | HCRTR2HCRTR1PTGDR2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |