Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6310115 | 0.92 | PARP1 (0.37) | TP53HSD17B10ALOX15PARP1USP2 | |
| SCHEMBL7710782 | 0.90 | PARP1 (0.44) | TP53HSD17B10ALOX15PARP1USP2 | |
| SCHEMBL7711006 | 0.89 | PARP1 (0.36) | TP53HSD17B10ALOX15PARP1USP2 | |
| SCHEMBL6309617 | 0.87 | HDAC1 (0.43) | HSD17B10ALOX15PARP1HDAC3HDAC1 | |
| SCHEMBL7704907 | 0.87 | HSD17B10 (0.38) | TP53HSD17B10ALOX15PARP1USP2 | |
| SCHEMBL7704945 | 0.87 | HDAC3 (0.44) | HSD17B10ALOX15PARP1HDAC3HDAC1 | |
| SCHEMBL7704942 | 0.87 | ALDH1A1 (0.37) | TP53HSD17B10ALOX15PARP1HDAC3 | |
| SCHEMBL6309909 | 0.86 | HSD17B10 (0.33) | TP53HSD17B10ALOX15PARP1TSHR | |
| SCHEMBL7708255 | 0.86 | RIPK1 (0.36) | HSD17B10ALOX15PARP1TSHRHDAC3 | |
| SCHEMBL7712797 | 0.86 | RIPK1 (0.36) | TP53HSD17B10ALOX15PARP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |