Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2494437 | 0.85 | OPRM1 (0.50) | OPRM1SIGMAR1CHRM2CHRM3KCNH2 | |
| SCHEMBL1205295 | 0.81 | ACHE (0.45) | OPRM1SIGMAR1CHRM2CHRM3ACHE | |
| SCHEMBL803672 | 0.79 | SIGMAR1 (0.59) | OPRM1SIGMAR1CHRM2CHRM3KCNH2 | |
| SCHEMBL34473259 | 0.79 | OPRM1 (0.46) | OPRM1SIGMAR1CHRM2CHRM3KCNH2 | |
| SCHEMBL65854 | 0.76 | CACNA1B (0.39) | ACHEBCHE | |
| SCHEMBL3815654 | 0.75 | SIGMAR1 (0.51) | OPRM1SIGMAR1KCNH2ACHEDRD2 | |
| SCHEMBL7507555 | 0.75 | SIGMAR1 (0.51) | OPRM1SIGMAR1KCNH2ACHEDRD2 | |
| SCHEMBL1718867 | 0.74 | CHRM4 (0.53) | OPRM1SIGMAR1CHRM2CHRM3KCNH2 | |
| SCHEMBL5367694 | 0.74 | OPRM1 (0.54) | OPRM1SIGMAR1CHRM2CHRM3KCNH2 | |
| SCHEMBL34474746 | 0.74 | CCR5 (0.53) | OPRM1SIGMAR1CHRM2CHRM3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344449-B1 | HEADACHE AND MORPHINE DEPENDENCE | DR. KARL THOMAE GMBH (DE) | 2002-02-05 | — | — | US | disclosed |