Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INPP5A | Q14642 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 7/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27798677 | 0.83 | NPSR1 (0.34) | — | |
| SCHEMBL12017965 | 0.82 | CA12 (0.41) | — | |
| SCHEMBL12017973 | 0.82 | CA12 (0.41) | — | |
| SCHEMBL9215445 | 0.82 | CA12 (0.41) | — | |
| SCHEMBL21071685 | 0.79 | INPP5A (0.39) | INPP5AESR1ESR2CYP3A4CYP2C9 | |
| Methyl Alcohol SCHEMBL28141572 | 0.78 | — | — | |
| SCHEMBL27912 | 0.78 | ESR2 (0.46) | ESR1ESR2CYP3A4CYP2C9BRD4 | |
| SCHEMBL130642 | 0.78 | ESR2 (0.46) | ESR1ESR2CYP3A4CYP2C9BRD4 | |
| SCHEMBL1316560 | 0.78 | ESR2 (0.46) | ESR1ESR2CYP3A4CYP2C9BRD4 | |
| SCHEMBL2267415 | 0.78 | ESR2 (0.46) | ESR1ESR2CYP3A4CYP2C9BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350306-B1 | PAINTS AND COATINGS, ?HIGH DRY?COMPOSITIONS BASED ON FLUORINE CONTAINING POLYMERS | AUSIMONT S.P.A. (IT) | 2002-02-26 | — | — | US | disclosed |
| EP-0665253-B1 | Coatings based on fluoropolyethers | AUSIMONT SPA (IT) | 2001-08-16 | — | — | EP | disclosed |
| EP-0731125-B1 | Coatings based on fluoropolyethers | AUSIMONT SPA (IT) | 2001-07-04 | — | — | EP | disclosed |
| US-5959058-A | Coatings based on fluoropolyethers | AUSIMONT S.P.A. (IT) | 1999-09-28 | — | — | US | disclosed |
| EP-0731125-A1 | Coatings based on fluoropolyethers | AUSIMONT S.p.A. (IT) | 1996-09-11 | — | — | EP | disclosed |
| EP-0665253-A1 | Coatings based on fluoropolyethers | AUSIMONT S.p.A. (IT) | 1995-08-02 | — | — | EP | disclosed |