Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | CDC25B | P30305 | 1/20 | 0.32 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.31 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3895451 | 1.00 | MEN1 (0.41) | MEN1KMT2AALOX15CYP3A4ALDH1A1 | |
| SCHEMBL362466 | 0.88 | ALOX15 (0.42) | MEN1KMT2AALOX15CYP3A4ALDH1A1 | |
| SCHEMBL16357610 | 0.88 | ALDH1A1 (0.50) | MEN1KMT2AALOX15CYP3A4ALDH1A1 | |
| SCHEMBL18954258 | 0.87 | ALOX15 (0.34) | MEN1KMT2AALOX15CYP3A4ALDH1A1 | |
| SCHEMBL3870295 | 0.83 | LMNA (0.53) | MEN1KMT2AALOX15CYP3A4ALDH1A1 | |
| SCHEMBL156683 | 0.83 | — | — | |
| SCHEMBL11651471 | 0.82 | TSHR (0.42) | MEN1KMT2AALOX15CYP3A4ALDH1A1 | |
| SCHEMBL3897447 | 0.81 | TSHR (0.46) | MEN1KMT2AALOX15CYP3A4ALDH1A1 | |
| SCHEMBL13839555 | 0.81 | TSHR (0.46) | MEN1KMT2AALOX15CYP3A4ALDH1A1 | |
| SCHEMBL29011335 | 0.80 | TSHR (0.41) | MEN1KMT2AALOX15CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983221-B1 | CYCLOHEXANEDIOL DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-04-03 | — | — | EP | disclosed |
| EP-0983221-A1 | CYCLOHEXANEDIOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-08 | — | — | EP | disclosed |
| US-5969190-A | TREATING HYPERPROLIFERATIVE SKIN DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1998052894-A1 | CYCLOHEXANEDIOL DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1998-11-26 | — | — | WO | disclosed |