Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | USP7 | Q93009 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL697874 | 0.88 | ALOX5 (0.56) | ACHEALOX5HDAC1HDAC8HDAC6 | |
| SCHEMBL28247407 | 0.85 | HDAC1 (0.63) | ACHEALOX5HDAC1HDAC8HDAC6 | |
| SCHEMBL6840328 | 0.85 | ACHE (0.54) | ACHEALOX5HDAC1HDAC8HDAC6 | |
| SCHEMBL27611274 | 0.84 | ACHE (0.66) | ACHEALOX5CAPN1USP7 | |
| SCHEMBL8790552 | 0.83 | ACHE (0.64) | ACHE | |
| SCHEMBL700477 | 0.82 | ACHE (0.52) | ACHEALOX5HDAC1HDAC8HDAC6 | |
| SCHEMBL7712397 | 0.82 | ACHE (0.52) | ACHEALOX5HDAC1HDAC8HDAC6 | |
| SCHEMBL16558086 | 0.81 | HDAC6 (0.46) | ACHEALOX5HDAC1HDAC8HDAC6 | |
| SCHEMBL7710166 | 0.79 | ALOX5 (0.53) | ACHEALOX5HDAC1HDAC8HDAC6 | |
| SCHEMBL9199620 | 0.79 | ACHE (0.69) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598364-B2 | Indolyl or indolinyl hydroxamate compounds | TAIPEI MEDICAL UNIVERSITY (TW) | 2017-03-21 | — | — | US | disclosed |
| US-20150368195-A1 | INDOLINE COMPOUNDS FOR TREATMENT AND/OR PREVENTION OF INFLAMMATION DISEASES | TAIPEI MEDICAL UNIVERSITY (TW) | 2015-12-24 | — | — | US | disclosed |
| US-20140364477-A1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | TAIPEI MEDICAL UNIVERSITY (TW) | 2014-12-11 | — | — | US | disclosed |
| US-8846748-B2 | Indolyl or indolinyl hydroxamate compounds | TAIPEI MEDICAL UNIVERSITY (TW) | 2014-09-30 | — | — | US | disclosed |
| US-20110245315-A1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | TAIPEI MEDICAL UNIVERSITY (TW) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368195-A1 | INDOLINE COMPOUNDS FOR TREATMENT AND/OR PREVENTION OF INFLAMMATION DISEASES | IDO1, IDO2, INMT | ACHE 1587/4885ALOX5 173/4885HDAC1 563/4885 |
| US-20110245315-A1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | IDH3A, IDH2, IDH3B | ACHE 814/4885ALOX5 3664/4885HDAC1 8/4885 |
| US-20140364477-A1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | IDH3A, IDH2, IDH3B | ACHE 814/4885ALOX5 3664/4885HDAC1 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.