Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 6/20 | 0.82 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709056 | 0.94 | HCRTR2 (0.82) | HCRTR2HCRTR1LMNAAOC3RIPK1 | |
| SCHEMBL7707551 | 0.92 | HCRTR2 (0.71) | HCRTR2HCRTR1LMNAAOC3RIPK1 | |
| SCHEMBL7707423 | 0.91 | HCRTR2 (1.00) | HCRTR2HCRTR1POLBTSPOMAPT | |
| SCHEMBL7710901 | 0.85 | HCRTR2 (1.00) | HCRTR2HCRTR1LMNATSPOMAPT | |
| SCHEMBL7709453 | 0.83 | HCRTR2 (1.00) | HCRTR2HCRTR1LMNAPOLBTSPO | |
| SCHEMBL7701854 | 0.82 | HCRTR2 (0.86) | HCRTR2HCRTR1LMNATSPOMAPT | |
| SCHEMBL7708524 | 0.80 | HCRTR2 (0.74) | HCRTR2HCRTR1LMNAAOC3RIPK1 | |
| SCHEMBL2585096 | 0.79 | HCRTR2 (0.74) | HCRTR2HCRTR1POLBMAPTKDM4E | |
| SCHEMBL7710724 | 0.76 | HCRTR2 (0.70) | HCRTR2HCRTR1POLBKDM4EALDH1A1 | |
| SCHEMBL2584748 | 0.74 | HCRTR2 (0.63) | HCRTR2HCRTR1LMNAPOLBTSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |