Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707137 | 0.88 | RAB9A (0.48) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL7707115 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL7707124 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL7710408 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL7707527 | 0.80 | ALDH1A1 (0.50) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL7707535 | 0.79 | HDAC1 (0.50) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL7707519 | 0.77 | ALDH1A1 (0.46) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL7710323 | 0.77 | HDAC1 (0.54) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL7091717 | 0.76 | ALDH1A1 (0.45) | SMN1; SMN2NPC1RAB9AMAPTGAA | |
| SCHEMBL7707191 | 0.73 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6353007-B1 | ANTIINFLAMMATORY AGENTS AND INHIBITORS OF CELLULAR POLIFERATION | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-03-05 | — | — | US | claimed |
| US-6353007-B1 | ANTIINFLAMMATORY AGENTS AND INHIBITORS OF CELLULAR POLIFERATION | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-03-05 | — | — | US | disclosed |