Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 12/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | TMPRSS6 | Q8IU80 | 6/20 | 0.56 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.54 |
| ▸ | MASP2 | O00187 | 1/20 | 0.54 |
| ▸ | F7 | P08709 | 1/20 | 0.53 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.52 |
| ▸ | PROC | P04070 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16466537 | 0.79 | MMP8 (0.71) | MMP8 | |
| SCHEMBL7291494 | 0.79 | F2 (0.56) | F2MMP8TMPRSS6MASP2F7 | |
| SCHEMBL7889148 | 0.78 | F2 (0.55) | F2MMP8TMPRSS6MASP2F7 | |
| SCHEMBL7889152 | 0.78 | F2 (0.55) | F2MMP8TMPRSS6MASP2F7 | |
| SCHEMBL5041567 | 0.77 | TPSAB1 (0.62) | F2TMPRSS6ST14MASP2F7 | |
| SCHEMBL5041565 | 0.77 | TPSAB1 (0.62) | F2TMPRSS6ST14MASP2F7 | |
| Hydrochloric Acid SCHEMBL5041862 | 0.76 | TPSAB1 (0.60) | F2TMPRSS6ST14MASP2F7 | |
| Hydrochloric Acid SCHEMBL5041868 | 0.76 | TPSAB1 (0.60) | F2TMPRSS6ST14MASP2F7 | |
| SCHEMBL9029700 | 0.76 | TPSAB1 (0.71) | F2TPSAB1 | |
| Hydrochloric Acid SCHEMBL27450409 | 0.76 | F2 (0.67) | F2MMP8TMPRSS6ST14MASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265867-A1 | NOVEL MALONIC ACID DERIVATES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS INHIBITOR OF FACTOR XA ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma Deutschland GmbH (DE) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001062735-A1 | NOVEL MALONIC ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS INHIBITOR OF FACTOR XA ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-08-30 | — | — | WO | disclosed |