Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | RECQL | P46063 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | BLM | P54132 | 4/20 | 0.39 |
| ▸ | APEX1 | P27695 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850315 | 0.75 | NUDT1 (0.40) | KDM4EMAPTKMT2AHSD17B10HPGD | |
| SCHEMBL5667619 | 0.70 | ADORA2A (0.43) | KDM4EMAPTLMNAAPEX1KMT2A | |
| SCHEMBL7708273 | 0.68 | TDP1 (0.37) | TDP1KDM4ERECQLMAPTLMNA | |
| SCHEMBL3937368 | 0.65 | TDP1 (0.59) | TDP1KDM4ERECQLMAPTLMNA | |
| SCHEMBL6016517 | 0.65 | EGFR (0.42) | LMNAHSD17B10 | |
| SCHEMBL7708301 | 0.64 | CDK2 (0.53) | TDP1KDM4ERECQLMAPTLMNA | |
| SCHEMBL320848 | 0.63 | NUDT1 (0.43) | KDM4EMAPTKMT2AHSD17B10HPGD | |
| SCHEMBL6831171 | 0.63 | ADORA2A (0.52) | KDM4EMAPTLMNAKMT2ATSHR | |
| SCHEMBL10217115 | 0.63 | FFAR2 (0.36) | LMNANUDT1 | |
| SCHEMBL42314 | 0.63 | ADORA2A (0.66) | LMNAAPEX1TSHRNUDT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244668-A1 | PURINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF | UNIVERSITAIRE INSTELLING ANTWERPEN (BE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001049688-A1 | PURINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF | UNIVERSITAIRE INSTELLING ANTWERPEN (BE) | 2001-07-12 | — | — | WO | disclosed |