Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL12 | P48061 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692557 | 0.72 | CXCL12 (0.51) | CXCL12MAOATAAR1TSHRMAPK1 | |
| SCHEMBL7816115 | 0.69 | CXCL12 (0.65) | CXCL12MAOA | |
| SCHEMBL27758491 | 0.66 | CALM1 (0.66) | TAAR1TSHRMAPK1LMNAGLA | |
| SCHEMBL14515681 | 0.65 | TAAR1 (0.75) | TAAR1TSHRMAPK1LMNAGLA | |
| SCHEMBL29740697 | 0.63 | PTPN1 (0.79) | TAAR1TSHRMAPK1LMNAGLA | |
| SCHEMBL31527873 | 0.63 | TUBB4A (0.66) | DHCR7TSHRLMNA | |
| SCHEMBL27183174 | 0.63 | TUBB4A (0.66) | DHCR7TSHRLMNA | |
| SCHEMBL363972 | 0.63 | MAOB (0.61) | CXCL12TAAR1TSHRMAPK1 | |
| SCHEMBL3693339 | 0.63 | MAOB (0.67) | CXCL12TAAR1TSHRMAPK1LMNA | |
| SCHEMBL7717965 | 0.63 | PTPN1 (0.62) | TAAR1TSHRMAPK1KCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011133600-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2010123822-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2010-10-28 | — | — | WO | disclosed |