Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7240383 | 0.90 | FNTA (0.41) | NPC1RAB9ASMN1; SMN2LMNAHTT | |
| SCHEMBL7703414 | 0.84 | FNTA (0.45) | NPC1RAB9ASMN1; SMN2LMNAHTT | |
| SCHEMBL8207459 | 0.77 | CTSA (0.39) | CTSA | |
| SCHEMBL7564332 | 0.77 | IDO1 (0.45) | SMN1; SMN2LMNAHTTHIF1ATBXAS1 | |
| SCHEMBL7564344 | 0.69 | CYP19A1 (0.40) | SMN1; SMN2LMNATBXAS1FNTAFNTB | |
| SCHEMBL7563092 | 0.65 | PTGS2 (0.52) | SMN1; SMN2LMNAHTTHIF1ATBXAS1 | |
| SCHEMBL7561297 | 0.65 | TBXAS1 (0.38) | SMN1; SMN2TBXAS1CYP19A1CYP3A4CYP2C9 | |
| SCHEMBL6306399 | 0.65 | CYP19A1 (0.50) | CYP19A1 | |
| SCHEMBL6979561 | 0.64 | CYP19A1 (0.59) | CYP11B1CYP11B2TBXAS1CYP19A1CYP3A4 | |
| SCHEMBL7247326 | 0.63 | CYP11B1 (0.39) | LMNACYP11B1CYP11B2FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414145-B1 | TREATING CANCER AND NEUROFIBROMATOSIS | ZENECA LIMITED (GB) | 2002-07-02 | — | — | US | disclosed |