Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 11/20 | 0.43 |
| ▸ | RARB | P10826 | 11/20 | 0.43 |
| ▸ | RARG | P13631 | 11/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713122 | 0.90 | RARA (0.36) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL7715218 | 0.82 | RARB (0.42) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL7717634 | 0.81 | RXRA (0.48) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL7709227 | 0.78 | CYP3A4 (0.59) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL10557217 | 0.78 | RARA (0.45) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL8681728 | 0.77 | RARB (0.48) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL7715088 | 0.76 | RARA (0.56) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL7713266 | 0.75 | RARA (0.51) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL12715250 | 0.75 | RARA (0.44) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL4373673 | 0.75 | RARB (0.58) | RARARARBRARGCYP3A4CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6368608-B1 | SKIN DISORDERS | CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) (FR) | 2002-04-09 | — | — | US | disclosed |
| US-6162445-A | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | disclosed |
| EP-0661258-B1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CIRD GALDERMA (FR) | 1998-04-08 | — | — | EP | disclosed |
| US-5716624-A | USEFUL FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, OPTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS/DISORDERS | C.I.R.D. GALDERMA (FR) | 1998-02-10 | — | — | US | disclosed |
| EP-0661258-A1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1995-07-05 | — | — | EP | disclosed |