Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 11/20 | 0.56 |
| ▸ | RARB | P10826 | 11/20 | 0.56 |
| ▸ | RARG | P13631 | 11/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.49 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715303 | 0.92 | RARA (0.48) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7709227 | 0.89 | CYP3A4 (0.59) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7713085 | 0.87 | RARA (0.45) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7715161 | 0.85 | CYP3A4 (0.54) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL7713109 | 0.83 | CYP3A4 (0.66) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7709286 | 0.81 | CYP26A1 (0.52) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL7713266 | 0.79 | RARA (0.51) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7715173 | 0.79 | RARA (0.40) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7414449 | 0.77 | RARB (0.71) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7709282 | 0.76 | RARA (0.43) | RARARARBRARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6368608-B1 | SKIN DISORDERS | CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) (FR) | 2002-04-09 | — | — | US | disclosed |
| US-6162445-A | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | disclosed |
| US-5716624-A | USEFUL FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, OPTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS/DISORDERS | C.I.R.D. GALDERMA (FR) | 1998-02-10 | — | — | US | disclosed |