Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801123 | 0.77 | MAPT (0.43) | KDM4EALDH1A1LMNAMAPTGAA | |
| SCHEMBL6663539 | 0.73 | — | — | |
| SCHEMBL10498542 | 0.73 | LMNA (0.70) | KDM4EALDH1A1LMNAMAPTTSHR | |
| SCHEMBL12812532 | 0.65 | LMNA (0.53) | KDM4EALDH1A1LMNAMAPTTSHR | |
| SCHEMBL18228600 | 0.65 | KDM4E (0.60) | KDM4EALDH1A1LMNAMAPTTSHR | |
| SCHEMBL3339822 | 0.65 | KDM4E (0.60) | KDM4EALDH1A1LMNAMAPTTSHR | |
| SCHEMBL2168776 | 0.65 | KDM4E (0.60) | KDM4EALDH1A1LMNAMAPTTSHR | |
| SCHEMBL10530529 | 0.65 | LMNA (0.53) | KDM4EALDH1A1LMNAMAPTGAA | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL169214 | 0.64 | ALDH1A1 (0.95) | KDM4EALDH1A1LMNAMAPTTSHR | |
| SCHEMBL13116773 | 0.64 | LMNA (0.57) | KDM4EALDH1A1LMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1240164-A1 | BENZAZOLE DERIVATIVES AND THEIR USE AS JNK MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001047920-A1 | BENZAZOLE DERIVATIVES AND THEIR USE AS JNK MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-07-05 | — | — | WO | disclosed |