Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715739 | 0.76 | RECQL (0.48) | RECQLSMN1; SMN2USP2THRBGAA | |
| SCHEMBL14617550 | 0.75 | FAAH (0.68) | SMN1; SMN2FAAH | |
| SCHEMBL38653489 | 0.74 | RECQL (0.48) | RECQLSMN1; SMN2USP2THRBMAPT | |
| SCHEMBL16399632 | 0.74 | SMN1; SMN2 (0.61) | RECQLSMN1; SMN2USP2THRBGAA | |
| SCHEMBL7718857 | 0.73 | GPR119 (0.52) | SMN1; SMN2THRBGAAMAPTGPR119 | |
| SCHEMBL23210070 | 0.72 | GPR119 (0.57) | RECQLSMN1; SMN2USP2THRBGAA | |
| SCHEMBL29691314 | 0.72 | GPR119 (0.57) | RECQLSMN1; SMN2USP2THRBGAA | |
| SCHEMBL20116051 | 0.72 | RECQL (0.51) | RECQLSMN1; SMN2USP2THRBGAA | |
| SCHEMBL23411131 | 0.72 | SMN1; SMN2 (0.49) | SMN1; SMN2USP2THRBGAAMAPT | |
| SCHEMBL14157385 | 0.72 | SMN1; SMN2 (0.49) | SMN1; SMN2THRBGAAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2555772-B1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME (US) | 2017-01-11 | — | — | EP | disclosed |
| US-9193697-B2 | Oxazole derivatives useful as modulators of FAAH | MERCK SHARP & DOHME CORP. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193697-B2 | Oxazole derivatives useful as modulators of FAAH | MERCK SHARP & DOHME CORP. (US) | 2015-11-24 | — | — | US | disclosed |
| US-20130018048-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-01-17 | — | — | US | disclosed |
| US-20130018048-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-01-17 | — | — | US | disclosed |
| WO-2011126960-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2011-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018048-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | FAAH, FAAH2, ALOX5 | RECQL 3592/4885SMN1; SMN2 304/4885USP2 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.