Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859239 | 0.91 | FFAR4 (0.46) | HDAC6HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL6862763 | 0.90 | HDAC1 (0.49) | HDAC6HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL7708661 | 0.81 | LMNA (0.47) | HDAC6HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL28337704 | 0.80 | CYP2D6 (0.47) | HDAC6HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL19642981 | 0.78 | PPARG (0.49) | HDAC6HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL22048451 | 0.76 | ALDH1A1 (0.46) | ALDH1A1TSHRSMN1; SMN2POLBCYP2D6 | |
| SCHEMBL28377221 | 0.76 | SMN1; SMN2 (0.41) | HDAC6HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL6860110 | 0.76 | HDAC1 (0.44) | HDAC6HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL21457785 | 0.75 | CYP2D6 (0.39) | HDAC6HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL22660216 | 0.75 | HDAC1 (0.43) | HDAC6HDAC1HDAC2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6794385-B2 | ANTITUMOR AGENTS; ANTICANCER AGENTS; OSTEOPOROSIS | PHARMACIA & UPJOHN, S.P.A. (IT) | 2004-09-21 | — | — | US | disclosed |