Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28337704 | 0.83 | CYP2D6 (0.47) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2DRD3 | |
| SCHEMBL22660216 | 0.78 | HDAC1 (0.43) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL22048451 | 0.76 | ALDH1A1 (0.46) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL7295476 | 0.76 | ALDH1A1 (0.50) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7711638 | 0.75 | HDAC6 (0.46) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2HDAC3 | |
| SCHEMBL28584939 | 0.75 | CYP2D6 (0.41) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6859239 | 0.73 | FFAR4 (0.46) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2ADRA1A | |
| SCHEMBL21837117 | 0.72 | LMNA (0.41) | CYP2D6CYP2C19ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6862763 | 0.72 | HDAC1 (0.49) | ALDH1A1SMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL19892686 | 0.71 | L3MBTL1 (0.40) | CYP2D6CYP2C19SMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062710-A1 | Method For Producing 3-(Pyridyl-2-Amino)Propionitrile And Analogues Thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2020-02-27 | — | — | US | disclosed |
| US-20200062710-A1 | Method For Producing 3-(Pyridyl-2-Amino)Propionitrile And Analogues Thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2020-02-27 | — | — | US | disclosed |
| EP-3553051-A1 | METHOD FOR PRODUCING 3-(PYRIDYL-2-AMINO)PROPIONITRILE AND ANALOGUES THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2019-10-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062710-A1 | Method For Producing 3-(Pyridyl-2-Amino)Propionitrile And Analogues Thereof | PDXK, PAH, PNPO | CYP2D6 87/4885CYP2C19 48/4885ALDH1A1 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.