SCHEMBL7712477

SCHEMBL7712477

CCC1CCc2ccccc2C=C1C(=O)OC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1B P49286 7/20 0.38
MTNR1A P48039 6/20 0.38
DRD2 P14416 1/20 0.38
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 2/20 0.36
HPGD P15428 2/20 0.36
HSD17B10 Q99714 2/20 0.36
GLA P06280 1/20 0.36
GAA P10253 1/20 0.36
CASP1 P29466 1/20 0.36
CASP7 P55210 1/20 0.36
MAPT P10636 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
ALOX15 P16050 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
CRBN Q96SW2 1/20 0.36
TRPA1 O75762 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7714514 0.82 MEN1 (0.38) MTNR1BMTNR1ADRD2KDM4EALDH1A1
SCHEMBL7708558 0.75 MAOA (0.34) MTNR1BMTNR1AHSD17B10
SCHEMBL7708561 0.74 MAOA (0.34) MTNR1BMTNR1ACASP1
SCHEMBL7712821 0.74 MTNR1A (0.37) MTNR1BMTNR1A
SCHEMBL7708576 0.73 CA12 (0.42) MTNR1BMTNR1ADRD2KDM4EALDH1A1
SCHEMBL7911204 0.70 CA12 (0.50) KDM4EALDH1A1HPGDALOX15TRPA1
SCHEMBL31090834 0.70 CA12 (0.50) KDM4EALDH1A1HPGDALOX15TRPA1
SCHEMBL7708862 0.69 CA12 (0.43) MTNR1BMTNR1AKDM4EALDH1A1ALOX15
SCHEMBL7378104 0.68 CA12 (0.48) KDM4EALDH1A1HPGDMAPTALOX15
Methyl Benzoate SCHEMBL27742789 0.68 TSHR (0.56) KDM4EALDH1A1HPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6369110-B1 PROPHYLACTIC AGENT FOR DISEASES CAUSED BY THE ACCELERATION OF THE SODIUM/PROTON EXCHANGE TRANSPORT SYSTEM SUMITOMO PHARMACEUTICALS COMPANY (JP) 2002-04-09 US disclosed
EP-1083166-A1 NOVEL SUBSTITUTED GUANIDINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2001-03-14 EP disclosed