Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.50 |
| ▸ | CA9 | Q16790 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 7/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31090834 | 1.00 | CA12 (0.50) | CA12CA9KDM4EALDH1A1HPGD | |
| SCHEMBL7378104 | 0.90 | CA12 (0.48) | CA12CA9KDM4EALDH1A1HPGD | |
| SCHEMBL29476751 | 0.84 | CA12 (0.59) | CA12CA9TRPA1ALOX15CA2 | |
| SCHEMBL5600204 | 0.84 | CA12 (0.59) | CA12CA9TRPA1ALOX15CA2 | |
| SCHEMBL30544152 | 0.82 | MEN1 (0.41) | CA12CA9KDM4EALDH1A1HPGD | |
| SCHEMBL7712683 | 0.82 | TSHR (0.47) | CA12CA9KDM4EALDH1A1HPGD | |
| SCHEMBL28512834 | 0.82 | MEN1 (0.41) | CA12CA9KDM4EALDH1A1HPGD | |
| SCHEMBL29433567 | 0.82 | TSHR (0.47) | CA12CA9KDM4EALDH1A1HPGD | |
| SCHEMBL8344638 | 0.80 | MAOB (0.40) | KDM4EALDH1A1HPGDPTGS2NPC1 | |
| SCHEMBL18599627 | 0.79 | GAA (0.43) | KDM4EALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793538-B2 | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors | THE BROAD INSTITUTE, INC. (US) | 2020-10-06 | — | — | US | disclosed |
| US-20180215726-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | THE BROAD INSTITUTE, INC. (US) | 2018-08-02 | — | — | US | disclosed |
| US-9914717-B2 | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors | THE BROAD INSTITUTE, INC. (US) | 2018-03-13 | — | — | US | disclosed |
| US-9914717-B2 | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors | THE BROAD INSTITUTE, INC. (US) | 2018-03-13 | — | — | US | disclosed |
| US-9914717-B2 | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors | THE BROAD INSTITUTE, INC. (US) | 2018-03-13 | — | — | US | disclosed |
| US-20150368221-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | THE BROAD INSTITUTE, INC. | 2015-12-24 | — | — | US | disclosed |
| US-20150368221-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | THE BROAD INSTITUTE, INC. | 2015-12-24 | — | — | US | disclosed |
| US-20150368221-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | THE BROAD INSTITUTE, INC. | 2015-12-24 | — | — | US | disclosed |
| WO-2014100438-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | THE BROAD INSTITUTE, INC. (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014100438-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | THE BROAD INSTITUTE, INC. (US) | 2014-06-26 | — | — | WO | disclosed |
| US-7875617-B2 | N-[4-(2-methoxyphenyl)piperazin-1-yl)butyl]-3,4-dihydro-6-fluoro-2-naphthamide for treating neuropsychological disorder selected from Parkinson's disease, schizophrenia and depression; partial agonists or antagonists of the dopamine D3 receptor | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2011-01-25 | — | — | US | disclosed |
| US-20090124630-A1 | 3, 4-DIHYDRO-2-NAPHTHAMIDE DERIVATIVES AS SELECTIVE DOPAMINE D3 LIGANDS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2009-05-14 | — | — | US | disclosed |
| US-7378552-B2 | Monoamine re-uptake inhibitors and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-05-27 | — | — | US | disclosed |
| US-7378552-B2 | Monoamine re-uptake inhibitors and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-05-27 | — | — | US | disclosed |
| US-6211212-B1 | DRUGS WITH AMIDE AND ESTER GROUPS AS ENZYME INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-0970062-A2 | PYRROLIDINE AND THIAZOLE DERIVATIVES WITH METALLO-BETA-LACTAMASE INHIBITORY PROPERTIES | SMITHKLINE BEECHAM PLC (GB) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998040056-A2 | PYRROLIDINE AND THIAZOLE DERIVATIVES WITH METALLO-BETA-LACTAMASE INHIBITORY PROPERTIES | SMITHKLINE BEECHAM PLC (GB) | 1998-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215726-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC7 | CA12 803/4885CA9 455/4885KDM4E 147/4885 |
| US-20150368221-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC7 | CA12 794/4885CA9 412/4885KDM4E 152/4885 |
| US-10793538-B2 | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors | HDAC1, HDAC3, HDAC7 | CA12 803/4885CA9 455/4885KDM4E 147/4885 |
| US-20090124630-A1 | 3, 4-DIHYDRO-2-NAPHTHAMIDE DERIVATIVES AS SELECTIVE DOPAMINE D3 LIGANDS | DRD3, SLC6A3, DRD2 | CA12 4728/4885CA9 4853/4885KDM4E 3894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.