Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708991 | 0.82 | NOTUM (0.35) | TSHRALDH1A1CYP3A4CYP1A2MEN1 | |
| SCHEMBL7708905 | 0.70 | TAS1R3 (0.31) | LMNANPSR1 | |
| SCHEMBL7708915 | 0.70 | ACHE (0.36) | KDM4EALDH1A1HSD17B10MAPTLMNA | |
| SCHEMBL15679176 | 0.69 | SIRT3 (0.49) | TSHRL3MBTL1KDM4EALDH1A1MAPK1 | |
| SCHEMBL18204508 | 0.67 | TLR4 (0.41) | TSHRPOLBL3MBTL1TDP1KDM4E | |
| SCHEMBL18204540 | 0.66 | TLR4 (0.51) | TSHRPOLBL3MBTL1TDP1KDM4E | |
| SCHEMBL1338586 | 0.66 | FFAR1 (0.44) | TSHRPOLBL3MBTL1TDP1KDM4E | |
| SCHEMBL26308105 | 0.66 | FFAR1 (0.44) | TSHRPOLBL3MBTL1TDP1KDM4E | |
| SCHEMBL8493097 | 0.66 | CA12 (0.66) | TSHRL3MBTL1TDP1KDM4EALDH1A1 | |
| SCHEMBL7248725 | 0.65 | ALDH1A1 (0.41) | TSHRPOLBL3MBTL1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369110-B1 | PROPHYLACTIC AGENT FOR DISEASES CAUSED BY THE ACCELERATION OF THE SODIUM/PROTON EXCHANGE TRANSPORT SYSTEM | SUMITOMO PHARMACEUTICALS COMPANY (JP) | 2002-04-09 | — | — | US | disclosed |
| EP-1083166-A1 | NOVEL SUBSTITUTED GUANIDINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-03-14 | — | — | EP | disclosed |