Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 10/20 | 0.45 |
| ▸ | RARB | P10826 | 10/20 | 0.45 |
| ▸ | RARG | P13631 | 10/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715173 | 0.93 | RARA (0.40) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7713266 | 0.90 | RARA (0.51) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL8440028 | 0.87 | RARA (0.54) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7715088 | 0.87 | RARA (0.56) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7714935 | 0.86 | RARB (0.42) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL7940029 | 0.83 | PDK2 (0.36) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL7709298 | 0.82 | RARB (0.44) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7714846 | 0.81 | RARA (0.52) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7928435 | 0.80 | PDK2 (0.35) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL7709227 | 0.79 | CYP3A4 (0.59) | RARARARBRARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162445-A | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | claimed |
| EP-0661258-B1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CIRD GALDERMA (FR) | 1998-04-08 | — | — | EP | claimed |
| US-6368608-B1 | SKIN DISORDERS | CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) (FR) | 2002-04-09 | — | — | US | disclosed |
| US-6162445-A | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | disclosed |