Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 14/20 | 0.41 |
| ▸ | RARG | P13631 | 14/20 | 0.41 |
| ▸ | RARA | P10276 | 11/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 3/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | HNF4A | P41235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709229 | 0.95 | RARB (0.41) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7709290 | 0.89 | RARB (0.41) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9817651 | 0.88 | RARB (0.53) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7713267 | 0.85 | ACACB (0.33) | RARBRARGRARAACACB | |
| SCHEMBL7715091 | 0.84 | RARB (0.42) | RARBRARGRARACYP3A4ACACB | |
| SCHEMBL8458478 | 0.83 | RXRA (0.54) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL1271404 | 0.81 | CYP3A4 (0.54) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL181636 | 0.81 | GPR84 (0.34) | — | |
| SCHEMBL20636875 | 0.80 | RARB (0.40) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7709302 | 0.80 | KDM4C (0.32) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162445-A | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | claimed |
| EP-0661258-B1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CIRD GALDERMA (FR) | 1998-04-08 | — | — | EP | claimed |
| US-6368608-B1 | SKIN DISORDERS | CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) (FR) | 2002-04-09 | — | — | US | disclosed |
| US-6162445-A | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | disclosed |