Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.54 |
| ▸ | RARA | P10276 | 8/20 | 0.45 |
| ▸ | RARB | P10826 | 8/20 | 0.45 |
| ▸ | RARG | P13631 | 8/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HNF4A | P41235 | 2/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | USP9X | Q93008 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101913 | 0.85 | RARB (0.53) | RXRARARARARBRARGRXRB | |
| SCHEMBL7709229 | 0.84 | RARB (0.41) | RXRARARARARBRARGRXRB | |
| SCHEMBL7713112 | 0.83 | RARB (0.41) | RXRARARARARBRARGRXRB | |
| SCHEMBL8776331 | 0.83 | RARB (0.42) | RXRARARARARBRARGCYP3A4 | |
| SCHEMBL9817651 | 0.80 | RARB (0.53) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL4421853 | 0.77 | KDM4E (0.50) | RXRARARARARBRARGCYP26A1 | |
| SCHEMBL7141574 | 0.77 | RARB (0.74) | RXRARARARARBRARGRXRB | |
| SCHEMBL6146166 | 0.77 | RARA (0.44) | RXRARARARARBRARGRXRB | |
| SCHEMBL6148053 | 0.77 | RARA (0.44) | RXRARARARARBRARGRXRB | |
| SCHEMBL8459845 | 0.76 | STAT3 (0.62) | RARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |