Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592050 | 0.94 | THRB (0.46) | HCRTR1HCRTR2MAPTTHRBPKM | |
| SCHEMBL2590272 | 0.93 | SIGMAR1 (0.45) | HCRTR1HCRTR2MAPTTHRBKMT2A | |
| SCHEMBL2595050 | 0.87 | HCRTR2 (0.53) | HCRTR1HCRTR2MAPTTHRBKMT2A | |
| SCHEMBL7713640 | 0.85 | HCRTR2 (0.54) | HCRTR1HCRTR2MAPTTSHRPOLB | |
| SCHEMBL2588992 | 0.81 | HCRTR2 (0.44) | HCRTR1HCRTR2MAPTTHRBGRIN2B | |
| SCHEMBL2594867 | 0.80 | HCRTR1 (0.45) | HCRTR1HCRTR2MAPTGRIN2BPOLB | |
| SCHEMBL7711206 | 0.80 | HCRTR2 (0.55) | HCRTR1HCRTR2MAPTPOLB | |
| SCHEMBL7707104 | 0.79 | HCRTR1 (0.47) | HCRTR1HCRTR2MAPT | |
| SCHEMBL7707974 | 0.79 | HCRTR2 (0.53) | HCRTR1HCRTR2KMT2ATSHRPOLB | |
| SCHEMBL7712435 | 0.75 | HCRTR2 (0.48) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | claimed |
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |