Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 3/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713640 | 0.94 | HCRTR2 (0.54) | HCRTR2HCRTR1PTGDR2POLBMAPT | |
| SCHEMBL7707104 | 0.90 | HCRTR1 (0.47) | HCRTR2HCRTR1PTGDR2SMN1; SMN2NPSR1 | |
| SCHEMBL2588992 | 0.86 | HCRTR2 (0.44) | HCRTR2HCRTR1SMN1; SMN2NPSR1POLB | |
| SCHEMBL7709100 | 0.85 | SMN1; SMN2 (0.51) | HCRTR2HCRTR1SMN1; SMN2NPSR1POLB | |
| SCHEMBL2592050 | 0.84 | THRB (0.46) | HCRTR2HCRTR1POLBMAPT | |
| SCHEMBL2595050 | 0.82 | HCRTR2 (0.53) | HCRTR2HCRTR1PTGDR2SMN1; SMN2NPSR1 | |
| SCHEMBL7707974 | 0.81 | HCRTR2 (0.53) | HCRTR2HCRTR1SMN1; SMN2NPSR1POLB | |
| SCHEMBL7712435 | 0.81 | HCRTR2 (0.48) | HCRTR2HCRTR1PTGDR2 | |
| SCHEMBL2594744 | 0.80 | HCRTR1 (0.48) | HCRTR2HCRTR1POLBMAPT | |
| SCHEMBL7702650 | 0.80 | HCRTR2 (0.78) | HCRTR2HCRTR1SMN1; SMN2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |